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Abstract Immune checkpoint inhibitors (ICIs) have revolutionized melanoma treatment, yet patient responses remain highly variable, underscoring the need for predictive biomarkers. Emerging evidence suggests that gut microbiome composition influences ICI efficacy, though findings remain inconsistent across studies. Here, we present a meta-analysis of seven melanoma-associated microbiome cohorts (N=678) using a standardized computational pipeline to integrate microbial species, biosynthetic gene clusters (BGCs), and functional pathways. We identifyFaecalibacteriumSGB15346 as a key species enriched in responders, alongside RiPP biosynthetic class and pathways involved in short-chain fatty acid fermentation. Conversely, dTDP-sugar biosynthesis correlates with non-response. Our results highlight microbial signatures and metabolic pathways associated with ICI outcomes, offering potential targets for microbiome-based interventions in personalized immunotherapy. 

We measured the full complex ac conductance of two-dimensional granular $\mathrm{In}/{\mathrm{InO}}_x$composites using the mutual inductance technique to explore the transition from a “failed superconductor turned anomalous metal” to a robust superconductor. In this system, room-temperature annealing was adopted to tune the ${\mathrm{InO}}_x$-mediated coupling between In grains, allowing for the observation of both a “true” superconductor-to-insulator transition and the emergence of an intervening anomalous metallic state. In this paper, we show that further annealing increases the intergrain coupling, eliminating the anomalous metallic phase but at the same time preventing the emergence of strong Bose-dominated insulating phase. The complex ac conductance revealed a $T\to 0$finite dissipative response in a finite magnetic field, coexisting with a robust superfluid density. The anomalous power-law spectra for the dissipative response suggest quantum critical behavior as probed in the kilohertz range, and point to signatures of gapless superconductivity in our granular superconducting system. Published by the American Physical Society2025 

A real-world text corpus sometimes comprises not only text documents, but also semantic links between them (e.g., academic papers in a bibliographic network are linked by citations and co-authorships). Text documents and semantic connections form a text-rich network, which empowers a wide range of downstream tasks such as classification and retrieval. However, pretraining methods for such structures are still lacking, making it difficult to build one generic model that can be adapted to various tasks on text-rich networks. Current pretraining objectives, such as masked language modeling, purely model texts and do not take inter-document structure information into consideration. To this end, we propose our PretrAining on TexT-Rich NetwOrk framework PATTON. PATTON1 includes two pretraining strategies: network-contextualized masked language modeling and masked node prediction, to capture the inherent dependency between textual attributes and network structure. We conduct experiments on four downstream tasks in five datasets from both academic and e-commerce domains, where PATTON outperforms baselines significantly and consistently. 

Resistivity saturation is found on both superconducting and insulating sides of an “avoided” magnetic-field-tuned superconductor-to-insulator transition (H-SIT) in a two-dimensional In/InO x composite, where the anomalous metallic behavior cuts off conductivity or resistivity divergence in the zero-temperature limit. The granular morphology of the material implies a system of Josephson junctions (JJs) with a broad distribution of Josephson coupling E J and charging energy E C , with an H-SIT determined by the competition between E J and E C . By virtue of self-duality across the true H-SIT, we invoke macroscopic quantum tunneling effects to explain the temperature-independent resistance where the “failed superconductor” side is a consequence of phase fluctuations and the “failed insulator” side results from charge fluctuations. While true self-duality is lost in the avoided transition, its vestiges are argued to persist, owing to the incipient duality of the percolative nature of the dissipative path in the underlying random JJ system. 

Safety and security play critical roles for the success of Autonomous Driving (AD) systems. Since AD systems heavily rely on AI components, the safety and security research of such components has also received great attention in recent years. While it is widely recognized that AI component-level (mis)behavior does not necessarily lead to AD system-level impacts, most of existing work still only adopts component-level evaluation. To fill such critical scientific methodology-level gap from component-level to real system-level impact, a system-driven evaluation platform jointly constructed by the community could be the solution. In this paper, we present PASS (Platform for Auto-driving Safety and Security), a system-driven evaluation prototype based on simulation. By sharing our platform building concept and preliminary efforts, we hope to call on the community to build a uniform and extensible platform to make AI safety and security work sufficiently meaningful at the system level. 

Text categorization is an essential task in Web content analysis. Considering the ever-evolving Web data and new emerging categories, instead of the laborious supervised setting, in this paper, we focus on the minimally-supervised setting that aims to categorize documents effectively, with a couple of seed documents annotated per category. We recognize that texts collected from the Web are often structure-rich, i.e., accompanied by various metadata. One can easily organize the corpus into a text-rich network, joining raw text documents with document attributes, high-quality phrases, label surface names as nodes, and their associations as edges. Such a network provides a holistic view of the corpus’ heterogeneous data sources and enables a joint optimization for network-based analysis and deep textual model training. We therefore propose a novel framework for minimally supervised categorization by learning from the text-rich network. Specifically, we jointly train two modules with different inductive biases – a text analysis module for text understanding and a network learning module for class-discriminative, scalable network learning. Each module generates pseudo training labels from the unlabeled document set, and both modules mutually enhance each other by co-training using pooled pseudo labels. We test our model on two real-world datasets. On the challenging e-commerce product categorization dataset with 683 categories, our experiments show that given only three seed documents per category, our framework can achieve an accuracy of about 92%, significantly outperforming all compared methods; our accuracy is only less than 2% away from the supervised BERT model trained on about 50K labeled documents. 

Abstract Many experiments investigating magnetic-field tuned superconductor-insulator transition (H-SIT) often exhibit low-temperature resistance saturation, which is interpreted as an anomalous metallic phase emerging from a ‘failed superconductor’, thus challenging conventional theory. Here we study a random granular array of indium islands grown on a gateable layer of indium-oxide. By tuning the intergrain couplings, we reveal a wide range of magnetic fields where resistance saturation is observed, under conditions of careful electromagnetic filtering and within a wide range of linear response. Exposure to external broadband noise or microwave radiation is shown to strengthen the tendency of superconductivity, where at low field a global superconducting phase is restored. Increasing magnetic field unveils an ‘avoided H-SIT’ that exhibits granularity-induced logarithmic divergence of the resistance/conductance above/below that transition, pointing to possible vestiges of the original emergent duality observed in a true H-SIT. We conclude that anomalous metallic phase is intimately associated with inherent inhomogeneities, exhibiting robust behavior at attainable temperatures for strongly granular two-dimensional systems.